Five people, including three young children, have died in a house fire in Sheffield despite heroic efforts to save the youngsters.
Two women are believed to have died alongside the children after a blaze in Wake Road, Sharrow, shortly after midnight.
Neighbours said they believed the victims included a baby girl, two boys and their aunt and grandmother.
Wake Road is about one mile from the centre of Sheffield One neighbour told how they saw the grandmother run screaming from the blazing home, before going back inside to try and save the young victims.
A South Yorkshire Fire and Rescue spokesman said the cause of the blaze was being investigated.
Scenes of crime officers have erected a tent outside the three-storey terraced home and are searching for clues.
Police have sealed off the road Sky's North of England Correspondent Mike McCarthy said Wake Road had been sealed off while investigations continued.
"A 999 call was made at 12.15am and an operation involved an aerial ladder to reach an upper floor," McCarthy said.
"Sadly two adult females and three children are known to have died.
"There's a white scenes of crime tent outside the house and there's a window open there. I can still smell the smoke from the fire."
Four fire engines were called to the scene, as well as police and ambulance services.
A police spokesman said: "At this stage we are not able to confirm where in the house the fire broke out or if anyone else was injured."
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